National Institute of Technology, Meghalaya

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Dr. Harshit Joshi Assistant Professor

Ph.D. (IIT Kanpur), M.Sc. & B.Sc. (Kumaun University Nainital)

harshit.joshi@nitm.ac.in

Research Interest

• Development of new strategies for carbon-carbon and carbon-hetero bond forming reactions. • Design and development of asymmetric one-pot multi-step reactions for the synthesis of carbocyclic and heterocyclic building blocks. • Design and synthesis of new chiral non-racemic catalysts and ligands for enantioselective reactions. • Development of new reaction methodologies for the functionalization of unactivated substrates by harnessing the power of electrocatalysis and photo-redox catalysis. • Total synthesis of biologically active natural products and non-natural molecules.

Education Qualification

Ph.D. (IIT Kanpur), M.Sc. & B.Sc. (Kumaun University Nainital)

Work Experiences

Assistant Professor

Department of Chemical & Biological Sciences,

National Institute of Technology Meghalaya, India: From September 2024

Post-doctoral Researcher

Department of Medicinal Chemistry,

University of Kansas, USA: August 2021 to August 2024

Project Scientist

Department of Chemistry,

Indian Institute of Technology Kanpur, India: August 2020 to July 2021

Awards and Certifications

Qualified national eligibility test (NET-JRF) in Chemical Sciences in 2014

List of Publications

1. Joshi, H.; Manna, A.; Nagamalla, S.; Thomas, A.; Sathyamoorthi, S. A Catalytic, Enantioselective Sulfamate Tethered Aza-Michael Cyclization. Org. Lett. 2024, 26, 10708. https://doi.org/10.1021/acs.orglett.4c03558

2. Nirpal, A. K.; Joshi, H.; Kelley, S. P.; Sathyamoorthi, S. Exploration of One-pot, Tandem Sulfamoylation and Aza-Michael Cyclization Reactions for the Syntheses of Oxathiazinane Heterocycles. J. Org. Chem. 2024, 89, 16774. https://doi.org/10.1021/acs.joc.4c02086

3. Joshi, H.; Sathyamoorthi, S. The Intramolecular Silanoxy-Michael Reactions with Pendant Nitroalkenes, Racemic and Enantioselective. J. Org. Chem. 2024, 89, 14197. https://doi.org/10.1021/acs.joc.4c01625

4. Joshi, H.; Nirpal, A. K.; Paul, D.; Kelley, S. P.; Mague, J. T.; Sathyamoorthi, S. The Development of a Sulfamate-Tethered Aza-Michael Cyclization Allows for the Preparation of (-)-Negamycin tert-Butyl Ester. J. Org. Chem. 2024, 89, 5911. https://doi.org/10.1021/acs.joc.4c00604

5. Choudhary, K.; Joshi, H.; Rohilla, S.; Singh, V. K. Silver-Catalyzed Asymmetric Double Desymmetrization via Vinylogous Michael Addition of Prochiral Cyclic ?,?-Dicyanoalkenes to Cyclopentendiones. Chem. Eur. J. 2024, 30, e202304078. https://doi.org/10.1002/chem.202304078 (Highlighted: Lautens, M.; Johnson, C. E. Synfacts 2024, 20, 0496).

6. Manna, A.; Joshi, H.; Singh, V. K. Organocatalytic Asymmetric Direct Vinylogous Michael Initiated Ring Closure Reaction of 4-Nitroisoxazole Derivatives to 3-Isopropylidene oxindoles. J. Org. Chem. 2023, 88, 15937. https://doi.org/10.1021/acs.joc.3c02125

7. Joshi, H.; Paul, D.; Sathyamoorthi, S. Oxidations of Alcohols, Aldehydes, and Diols using NaBr and Selectfluor. J. Org. Chem. 2023, 88, 11240. https://doi.org/10.1021/acs.joc.3c01307

8. Joshi, H.; Thomas, A.; Mague, J.; Sathyamoorthi, S. Dancing Silanols: Stereospecific Rearrangements of Silanol Epoxides into Silanoxy-Tetrahydrofurans and Silanoxy-Tetrahydropyrans Org. Chem. Front. 2023, 10, 2556. https://doi.org/10.1039/D3QO00427A

9. Manna†, A.; Joshi† , H.; Singh, V. K. Asymmetric Synthesis of Spiro-3, 3'-cyclopropyl Oxindoles via Vinylogous Michael Initiated Ring Closure Reaction. J. Org. Chem. 2022, 87, 16755 († Co-first author). https://doi.org/10.1021/acs.joc.2c02402

10. Joshi, H.; Sathyamoorthi, S. Hydroxyselenylation and Tethered Silanoxyselenylation of Allylic Silanols. J. Org. Chem. 2022, 87, 5017. https://doi.org/10.1021/acs.joc.2c00119

11. Das, A.; Joshi, H.; Singh, V. K. Asymmetric ?-Functionalization of 2-Alkyl Azaarenes: Synthesis of Tertiary Fluorides Having Vicinal Stereogenic Centers. Org. Lett. 2021, 23, 9441. https://doi.org/10.1021/acs.orglett.1c03626

12. Joshi, H.; Singh, V. K. Cinchona Derivatives as Bifunctional H-bonding Organocatalysts in Asymmetric Vinylogous Conjugate Addition Reactions. Asian J. Org. Chem. 2022, e202100053, 1. https://doi.org/10.1002/ajoc.202100053

13. Joshi, H.; Yadav, A.; Das, A.; Singh, V. K. Organocatalytic Asymmetric Hetero-Diels–Alder Reaction of in-situ Generated Dienes: Access to ?,?-Unsaturated ?-Lactones Featuring CF3-Substituted Quaternary Stereocenter. J. Org. Chem. 2020, 85, 3202. https://doi.org/10.1021/acs.joc.9b03076

14. Jha, R. K.; Rout, S.; Joshi, H.; Das, A.; Singh, V. K. An Enantioselective Sulfa–Michael Addition of Alkyl Thiols to ?,?-Unsaturated 2-Acyl imidazoles Catalyzed by a Bifunctional Squaramide. Tetrahedron 2020, 76, 130800. https://doi.org/10.1016/j.tet.2019.130800

15. Mahto, P.; Rana, N. K.; Shukla, K.; Das, B. G.; Joshi, H.; Singh, V. K. Asymmetric Multifunctional Modular Organocatalysis: One-pot Direct Strategy to Enantiopure ?,?-Disubstituted ?-Butyrolactones. Org. Lett. 2019, 21, 5962. https://doi.org/10.1021/acs.orglett.9b02094 (Highlighted: List, B.; Scharf, M. J. Synfacts 2019, 15, 1184).

16. Rout† , S.; Joshi† , H.; Singh, V. K. Asymmetric Construction of Remote Vicinal Quaternary and Tertiary Stereocenters via Direct Doubly Vinylogous Michael Addition. Org. Lett. 2018, 20, 2199 († Co-first author). https://doi.org/10.1021/acs.orglett.8b00493

17. Rana, N. K.; Jha, R. K.; Joshi, H.; Singh, V. K. Enantioselective Access to Tetrahydropyrano[2,3- c]pyrazoles via an Organocatalytic Domino Michael–Hydroalkoxylation Reaction. Tetrahedron Lett. 2017, 58, 2135. https://doi.org/10.1016/j.tetlet.2017.04.059

18. Rana, N. K.; Joshi, H.; Jha, R. K.; Singh, V. K. Enantioselective Tandem Oxidation/Michael–Aldol Approaches to Tetrasubstituted Cyclohexanes. Chem. Eur. J. 2017, 23, 2040 https://doi.org/10.1002/chem.201605999 (Highlighted: Kocienski, P. Synfacts 2017, 13, 0458).

Selected Conferences/Symposia Presentations and Lectures Delivered

• Delivered lecture on “Academic Integrity: Plagiarism” as a resource person to the participants of GURU DAKSHTA 16th Faculty Induction Program conducted from 3 rd – 30th March 2023 by UGC-HRDC, Ranchi University, India (Invited).

• Presented poster in 11th Chemical Frontiers Goa meeting, 22nd – 25th August 2019 held at Goa, India. Harshit Joshi and Vinod K. Singh “Organocatalytic Asymmetric Hetero-Diels-Alder Reaction of in-situ Generated Dienes: Access to ?,?-Unsaturated ?-Lactones Featuring CF3-Substituted Quaternary Stereocenter.”

• Presented poster in 25th CRSI National Symposium in Chemistry held at IIT Kanpur, India, 19th – 21st July 2019. Harshit Joshi and Vinod K. Singh “Organocatalytic Asymmetric Hetero-Diels-Alder Reaction of insitu Generated Dienes: Access to ?,?-Unsaturated ?-Lactones Featuring CF3-Substituted Quaternary Stereocenter.”

• Oral presentation in XIV JNOST conference 2018 held at IICT Hyderabad, India, 28th Nov – 1 st Dec 2018. Subhrajit Rout, Harshit Joshi, and Vinod K. Singh “Asymmetric Construction of Remote Vicinal Quaternary and Tertiary Stereocenters via Direct Doubly Vinylogous Michael Addition.”

• Presented poster in Research Scholar Day Symposium 2018 held at IIT Kanpur, India 10th Nov 2018. Harshit Joshi, and Vinod K. Singh “Asymmetric Construction of Remote Vicinal Quaternary and Tertiary Stereocenters via Direct Doubly Vinylogous Michael Addition.”

• Presented poster in 21st International Conference on Organic Synthesis (ICOS) held at IIT Bombay, India 11th Dec 2016 – 16th Dec 2016. Nirmal K. Rana, Harshit Joshi, Rupesh K. Jha, and Vinod K. Singh “Enantioselective Tandem Oxidation/Michael–Aldol Approaches to Tetrasubstituted Cyclohexanes.”

Head of Department

Faculty